We’re proud to announce that our collaboration with the University of Pennsylvania's Gene Therapy Program (GTP) has been featured on GenEngNews! The article highlights the expansion of GTP’s evaluation of our scale-X™ nitro 600 m² bioreactor for scalable gene therapy manufacturing. Check out the full article here: https://lnkd.in/eq-gxAUt #geneticengineering #genetherapy #innovation #technology
Univercells Technologies
Biotechnology Research
Nivelles, Walloon Region 7,326 followers
by Donaldson - We deliver the next generation of bioprocess technologies
About us
Univercells Technologies is a global provider of innovative biomanufacturing technologies to achieve cost-effective viral production from R&D to commercial scales. The company offers a comprehensive technology portfolio leveraging the strengths of process intensification and chaining as a direct answer to the growing demand of viral vectors and viral vaccines. Univercells Technologies is committed to helping customers increase performance with minimized footprint and costs today, while anticipating the needs of tomorrow. Building upon years of expertise and capitalizing on technology vetted by world leaders, Univercells Technologies was incorporated in Belgium in 2020 with the support of the Univercells group.
- Website
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http://www.univercellstech.com
External link for Univercells Technologies
- Industry
- Biotechnology Research
- Company size
- 51-200 employees
- Headquarters
- Nivelles, Walloon Region
- Type
- Privately Held
Locations
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Primary
Get directions
Chemin de la Vieille Cour 56a
Nivelles, Walloon Region 1400, BE
Employees at Univercells Technologies
Updates
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🌟 Exciting News! 🌟 We're thrilled to announce our collaboration with the Gene Therapy Program at the University of Pennsylvania, led by Dr. Jim Wilson. This partnership focuses on evaluating the scalability of gene therapy production using our innovative scale-X™ bioreactor. Together, we aim to advance gene therapy and make treatments more accessible worldwide. Read the full press release 👉 https://lnkd.in/ee6-F9fZ #GeneTherapy #Biotechnology #Innovation #Partnership #Healthcare #UnivercellsTechnologies #DonaldsonLifeSciences #UniversityofPennsylvania #GTP #LifeChangingTreatments #AffordableHealthcare
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🚀 Ready to revolutionize your approach to extracellular vesicle production? Discover low-footprint, automated solutions for low-cost EV manufacturing with our new webinar available on-demand ! 🔍 What you'll learn: • Overcome challenges in traditional EV manufacturing systems for greater efficiency. • Explore the scale-X™ bioreactors platform for scalable, continuous, and high-capacity MSC-EV production in a compact space. • Achieve up to 2-fold increase in EV productivity while maintaining quality. • Optimize EV yield, purity, and scalability with perfusion production and Tangential Flow Filtration techniques. 📢 Don't miss this opportunity to enhance your expertise and stay ahead in the field of biomanufacturing. Watch anytime, anywhere! 🔗 https://lnkd.in/eU4Zrejq #biomanufacturing #ExtracellularVesicles #webinar #biotechnology #Innovation #scaleX
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We're thrilled to attend the 28th ESACT meeting in Edinburgh next week 🤩 ! Don't miss the opportunity to meet our team and to learn more about the latest advancements in scalable and efficient bioprocessing technologies with our very own Laura Siedler's poster presentation: "Scalable, Serum-Free Viral Vector Production in a High-Cell Density Bioreactor."💡 We can't wait to see you there! 👋 #ESACT24 #Biotechnology #Innovation #Bioreactors #ViralVectors
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We've got some exciting news to share! 🤩 Univercells Technologies was on site at Isolere Bio By Donaldson to install the scale-X™ hydro bioreactor! The combination of both scale-X and IsoTag™ innovative technologies aims to accelerate process development timelines and reduce manufacturing complexity in the production of accessible cell and gene therapies worldwide 🌎. This is the first step towards an efficient and productive end-to-end lentiviral manufacturing process! Stay tuned for updates on this project ... #bioprocessing #scaleX #isotag #bioprocessing #viralvector #biomanufacturing #cellandgenetherapies Donaldson
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Looking for a simple, optimized, and scalable way to produce exosomes? 💡This is your final call to register to our upcoming webinar and discover how Univercells Technologies’ scale-X™ bioreactors help overcoming traditional EV manufacturing challenges ! 📈 Register now: https://lnkd.in/eTAVwTX5 #EV #manufacturing #scaleXbioreactors #biomanufacturing Laura Siedler
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🚀 Dive into the future of sustainable aquaculture with our latest case study! Discover how the scale-X™ bioreactor optimizes the expansion and harvest of fish stem cells, ensuring rapid growth and efficient production of cultivated fish. 🐟🌍 Don't miss out— explore the full BLUU Seafood study now! https://lnkd.in/eXSwVpGm
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Eager to find out how to optimize your production of exosomes? 💭 Join us on June 13th! Thomas Robert, Ph.D. will present how leading companies such as Orbsen Therapeutics Limited, Asfreya and RoosterBio Inc. have achieved: ✅ Successful process transfer into scale-X™ carbo bioreactor ✅ Increased EV productivity with ability to produce longer ✅ Production in perfusion and concentration with chained TFF ✅ High EV titers meeting quality criteria To learn more, register to our upcoming webinar 👉https://lnkd.in/eTAVwTX5 #EV #manufacturing #scaleXbioreactors #biomanufacturing
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Univercells Technologies by Donaldson is now on the lookout for a new Product Manager to expand the team! Keen to revolutionize the biotech industry? Join our talented teams and together, let’s reinvent biomanufacturing processes and develop the next innovative technologies 🌟 Interested? Apply now 👉 https://lnkd.in/eZZ72ie5
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🚀 Exciting News from OBiO Tech ! 🚀 Thanks for presenting our scale-X™ fixed-bed bioreactor range from 2.4 m2 R&D scale to 600 m2 commercial production scale. These advanced adherent culture processes for lentivirus production ensure high yield and high-quality viral vectors. 🔬 What are the advantages of using scale-X fixed-bed bioreactors? ✅ Homogeneous cell and media distribution throughout the fixed-bed ✅ Smooth, de-risked scale-up ✅ Low-footprint and concentrated harvests ✅ Integrated and chained cell culture, virus production, clarification and concentration processes in automated mode With these innovations, we're providing an efficient and scalable approach for producing high-quality viral vectors. Curious to learn more about the process? Read the below post and feel free to reach out to our teams if you have any questions 👉 https://lnkd.in/etH-XCgX #viralvectors #fixedbedbioreactor #bioprocessing #scalability
Adherent culture process for lentivirus——Fixed-bed reactor Culturing lentivirus in a fixed-bed reactor involves several steps to ensure high yield and quality of viral vectors. Fixed-bed reactors are advantageous for this purpose due to their ability to provide a controlled environment and efficient mass transfer. OBiO Tech has equipped 200 ~ 600 m2 fixed-bed reactors in its Lingang facility, provides an adherent culture scale-up solution. This method provides an efficient and scalable approach for producing high-quality lentiviral vectors for research or therapeutic applications. ❓send an inquiry here: https://lnkd.in/g8BzXQfQ For more information, Contact us at, 📞Phone: +1 408-422-9864 (U.S.) 📭Email: obio.us@obiosh.com An overview of the process: 1. Preparation of the Fixed-Bed Reactor Reactor Selection-Sterilization-Seeding Matrix. 2. Cell Preparation Cell Line Selection: Choose a suitable producer cell line for lentivirus production, commonly HEK293T cells. Cell Expansion: Expand the cell line in T-flasks or roller bottles to obtain a sufficient number of cells for seeding the reactor. 3. Seeding the Reactor Cell Inoculation: Inoculate the cells into the fixed-bed reactor. Ensure even distribution of cells within the bed to maximize cell growth and virus production. Culture Medium: Use an optimized culture medium to support cell growth and virus production. This often includes DMEM supplemented with FBS, antibiotics, and other necessary nutrients. 4. Culturing Initial Cell Growth Phase: Allow the cells to attach and grow on the fixed bed. This phase may take several days. Infection Phase: Transduce the cells with the necessary plasmids for lentivirus production. Typically, this includes plasmids encoding the lentiviral vector, packaging plasmids, and envelope plasmids. Culture Conditions: Maintain optimal culture conditions, such as temperature (37°C), CO₂ concentration (5%), and pH (7.2-7.4). Medium Exchange: Periodically exchange the medium to provide fresh nutrients and remove waste products. 5. Virus Harvesting Collection: usually 48-72 hours post-transfection,. Harvest Strategy: Use a perfusion system to continuously or intermittently collect the viral supernatant while fresh medium is supplied to the reactor. Clarification: Filter the collected supernatant to remove cell debris and large particles. 6. Downstream Processing Concentration-Purification-Sterilization 7. Quality Control Titer Determination: Measure the viral titer using methods like qPCR, flow cytometry, or functional assays. Sterility Testing: Ensure the preparation is sterile by performing bacterial and fungal contamination tests. Functional Assays: Confirm the functionality of the lentivirus through transduction efficiency assays. #cgt #cdmo #viralvector #biotech #equipment #development #manufacturing
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