AACR Journals

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The Clinical Cancer Research article Molecular Subtypes in COXEN—A Neoadjuvant Biomarker Trial by Seth P. Lerner et al. is featured in the AACR Journals Collection on Precision Oncology. Read it here: https://bit.ly/3LKvCH8

Cancer Discovery News serves as a comprehensive hub for cancer researchers aiming to stay informed about significant advances in preclinical and clinical research, as well as therapeutic development. Sign up to have news alerts delivered directly to your inbox! https://bit.ly/46qfTH0

Interested in learning more about recently disclosed novel therapeutics published in Molecular Cancer Therapeutics? Check out the #FirstDisclosures page to read the latest articles! https://bit.ly/4dgNghr

KRAS inhibitors have demonstrated exciting preclinical and clinical responses, but resistance occurs rapidly. Don’t miss this Cancer Research Communications article by Robert Norgard, Marco Hofmann, Abhishek Kashyap, et al. that bridges tumor biology and immune-oncology to investigate how to how to circumvent KRAS-targeted resistance—Reshaping the TME of KRASG12D PDAC with Combined SOS1 and MEK Inhibition for Improved Immunotherapy Response. https://bit.ly/3YhHOXn #openaccess

Read the Cancer Prevention Research article by Folasade (Fola) May, MD, PhD, et al., Three-Year Interval for the Multi-Target Stool DNA Test for Colorectal Cancer Screening: A Longitudinal Study, featured in the AACR Journals Collection on Cancer Early Detection. https://bit.ly/3WeDZQk

A new perspective paper in Clinical Cancer Research, in collaboration with experts from FDA and the American Statistical Association, details considerations to improve collection and analysis of #OverallSurvival data in oncology clinical trials. Incredible recent advances with cancer therapies have resulted in patients living much longer following a cancer diagnosis. Adapting the focus on the gold standard endpoint of overall survival in this new era will enhance understanding of the benefits and risks for new cancer therapies. Read the paper: https://bit.ly/4bZLNuN #AACRSciencePolicy

Congratulations to our Senior Scientist Dr. Mathieu Lupien at University Health Network on two recent publications that peek into the epigenetic regulation in prostate cancer! Mathieu is a senior author on both papers. Read more about the 3D conformation of cell genome in prostate cancer on Nature Genetics: https://lnkd.in/g9ruyjJw The team also mapped the chromatin accessibility in advanced prostate cancer, published on Cancer Research in AACR Journals: https://lnkd.in/gkep9hP4 Research at UHN

Many major advances in cancer biology can be made where different areas of research intersect. If you’re working on an interesting study that spans multiple disciplines, consider submitting your work to the Convergence Science section of Cancer Research. https://bit.ly/3LBFQti

Cancer Discovery News serves as a comprehensive hub for cancer researchers aiming to stay informed about significant advances in preclinical and clinical research, as well as therapeutic development. Sign up to have news alerts delivered directly to your inbox! https://bit.ly/46aGXd8