Excited for #COSPAR2024? Don't miss Sylvain Costes from OSDR speak about a 5-year GWAS analysis of blood cell response to simulated radiation. Be there for groundbreaking insights! #SpaceResearch #radiation 📆 July 19 ⌛ 10:10 - 10:30 AM 📍 EC1-211, Session F5.2
NASA GeneLab
Research Services
Moffett Field, CA 7,978 followers
Open Science for Life in Space
About us
GeneLab is an interactive, open-access resource where scientists can upload, download, store, search, share, transfer, and analyze omics data from spaceflight and corresponding analogue experiments. Users can explore GeneLab datasets in the Data Repository, analyze data using the Analysis Platform, and create collaborative projects using the Collaborative Workspace. GeneLab promises to facilitate and improve information sharing, foster innovation, and increase the pace of scientific discovery from extremely rare and valuable space biology experiments. Discoveries made using GeneLab have begun and will continue to deepen our understanding of biology, advance the field of genomics, and help to discover cures for diseases, create better diagnostic tools, and ultimately allow astronauts to better withstand the rigors of long-duration spaceflight. GeneLab helps scientists understand how the fundamental building blocks of life itself – DNA, RNA, proteins, and metabolites – change from exposure to microgravity, radiation, and other aspects of the space environment. GeneLab does so by providing fully coordinated epigenomics, genomics, transcriptomics, proteomics, and metabolomics data alongside essential metadata describing each spaceflight and space-relevant experiment. By carefully curating and implementing best practices for data standards, users can combine individual GeneLab datasets to gain new, comprehensive insights about the effects of spaceflight on biology. In this way, GeneLab extends the scientific knowledge gained from each biological experiment conducted in space, allowing scientists from around the world to make novel discoveries and develop new hypotheses from these priceless data.
- Website
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http://genelab.nasa.gov
External link for NASA GeneLab
- Industry
- Research Services
- Company size
- 11-50 employees
- Headquarters
- Moffett Field, CA
- Type
- Government Agency
Locations
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Primary
Moffett Field, CA 94035-0001, US
Employees at NASA GeneLab
Updates
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🚀🧬 More space health secrets unlocked! 🌌 Using 48 datasets from OSDR, this publication explored how microgravity and spaceflight impact genes, cells, and organs in humans and mice. Come check it out! #Microgravity #GeneExpression #NASAData #SpaceResearch 🌐 tinyurl.com/nat24sl
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Looking for the OSDR team in a sea of posters at #COSPAR2024? We've got you covered. Find our poster on accessing data with the NASA's Open Science Data Repository for one more day. Stop by and say Hi! 👋 #OSDR #spacebiology 📆 July 18 ⌛ 5 - 6:30 PM 📍 EC1-Hall1, Session F5.2
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NASA GeneLab reposted this
Afshin Beheshti and colleagues’ previous research identified a key microRNA signature associated with spaceflight, which can serve as a biomarker and aid in developing countermeasures to mitigate space radiation ☢️ damage. Building on this work, they investigated the biological factors affected by these countermeasures. Through RNA-sequencing and transcriptomic analysis of 3D microvessel cell cultures 🧫 exposed to simulated deep space radiation (0.5 Gy of Galactic Cosmic Radiation), they examined the effects of antagonists to three microRNAs: miR-16-5p, miR-125b-5p, and let-7a-5p (antagomirs). The results showed a significant reduction in inflammation and DNA 🧬 double-strand breaks (DSBs) activity 😮 , along with the rescue of mitochondrial functions post-antagomir treatment. Using data from astronaut 🧑🚀 participants in the NASA - National Aeronautics and Space Administration Twin Study, SpaceX Inspiration4, and JAXA: Japan Aerospace Exploration Agency missions, they identified genes and pathways affected by these antagomirs in humans. Their findings propose a viable countermeasure strategy that astronauts can use to mitigate space radiation damage during spaceflight missions 🚀 including deep space (Kimberly Washington) Please see the full text published as part of the SOMA collection right here -> https://lnkd.in/esxyMfTd NASA GeneLab Spaceomix Space Applications Services NV/SA Weill Cornell Medicine Blue Marble Space Institute of Science
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Interested in learning how biological research and space health can be enabled by machine learning in support of deep space missions? Then stop by Ryan T. Scott's presentation at #COSPAR2024 to learn more. #MachineLearning 📆 July 18 ⌛ 10 - 10:30 AM 📍 CON-108, Session POIS.1
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NASA GeneLab reposted this
Co-Founder & Chief Investment Officer @ DeepSpace Biology | Founder of the Global Nonprofit, Space4Girls | Worlds Top 50 Innovators 2024- Codex
🚀 Deep Space Biology is incredibly excited about the SOMA Package released by Nature.com. This milestone represents several firsts in space medicine and space biology: 🔬 **Unprecedented Data**: - Over 10-fold increase in next-generation sequencing (NGS) data from spaceflight. - 4-fold increase in single-cells processed from spaceflight. - First-ever direct RNA sequencing data from astronauts. - Largest number of processed biological samples from a mission (2,911). - First spatially-resolved transcriptome data from astronauts. 🧬 **Innovative Resources**: - Launch of the first aerospace medicine biobank, Weill Cornell Medicine’s CAMbank. 🌍 **Global Collaboration**: This achievement was made possible by working across borders and teams, between companies and governments, and spanning international laboratories. This collaboration has enabled the greatest amount of science and knowledge to be gained in this package. 🚀 **Future Impact**: This data will serve as a springboard for new experiments, hypotheses, and follow-up studies. They will also guide future mission planning and countermeasure development. This package exemplifies how modern tools of molecular biology and precision medicine can guide humanity into more challenging missions, which are critical for a permanent presence on the moon, Mars, and beyond. Join us as we continue to push the boundaries of space biology and aerospace medicine. The future of space exploration is here! 🌌🔬 #DeepSpaceBiology #SOMAPackage #SpaceMedicine #NGS #RNASequencing #SpaceflightResearch #InnovationInSpace #GlobalCollaboration #Nature #FutureOfSpaceExploration
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📣 Going to #COSPAR24? Check out this presentation by Sylvain Costes of OSDR: Unlocking the secrets of space biology-from the twin study to groundbreaking open science discoveries. What will you discover? 📆 July 14 ⌛ 2:25 - 2:50 PM 📍 CON-205, Session IDL 1&2
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NASA GeneLab reposted this
🚨Space Omics Hackathon! 📅 We are EXTENDING the ESA Space Omics Hackathon submission deadline! The applications will still be open until July 17th. 🚀 Don’t miss the opportunity, hurry up an apply here 👉https://lnkd.in/gRgd6nzu
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NASA GeneLab reposted this
Spaceflight 🚀 can disrupt metabolic, immunological, and biological homeostasis, leading to skin rashes and irritation. To understand these effects, Christopher Mason Afshin Beheshti Jiwoon Park Eliah Overbey JangKeun Kim Braden Tierney Namita Damle Krista Ryon Jeremy Wain Hirschberg Cem Meydan George Church and others conducted skin biopsies on the SpaceX Inspiration4 crew members before (L-44) and after (R+1) their mission. Utilizing advanced multi-omics assays such as GeoMx™ Digital Spatial Profiler, single-cell RNA/ATAC-seq, and metagenomics/metatranscriptomics, they analyzed spatial gene expressions and related microbial and immune changes across 95 skin regions. Their findings revealed significant up-regulation of inflammation-related genes 🧬 and KRAS signaling post-flight, mapped to specific cellular responses including DNA damage, epithelial barrier disruptions, and altered immune activity, primarily in the outer skin layers. They also linked these disruptions to microbial shifts and immune cell activity. This study marks the first comprehensive examination of astronaut 🧑🚀 skin, providing crucial insights for future space missions and potential countermeasures to ensure astronaut health 🌙 Please see the full text article published under SOMA right here https://lnkd.in/ec5ZdVkf Nature Portfolio Weill Cornell Medicine Blue Marble Space Institute of Science Spaceomix #space #life #science and #genetics Chris Sembroski
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NASA GeneLab reposted this
Spaceflight presents unique challenges, including increased health risks such as dermatological issues, which are not yet fully understood. Utilizing a systems biology approach, Christopher Mason Henry Cope Masafumi Muratani Cem Meydan Eliah Overbey JangKeun Kim Christopher Chin Nathaniel Szewczyk Afshin Beheshti and others analyzed murine transcriptomic data from NASA’s Open Science Data Repository, NASA GeneLab biochemical profiles of 50 NASA - National Aeronautics and Space Administration astronauts 🧑🚀, and human transcriptomic datasets from JAXA: Japan Aerospace Exploration Agency astronauts, alongside samples from the #NASA Twins Study and SpaceX Inspiration4 mission. Their study identified key biological changes linked to DNA 🧬 damage, mitochondrial dysregulation, and skin barrier function during spaceflight. Notably, post-flight re-tuning of gene expression highlights the skin's remarkable adaptability upon returning to Earth 🌍 . These findings are crucial for guiding future research on countermeasures to mitigate spaceflight-associated skin damage. Please see the full text article published under SOMA right here https://lnkd.in/ewNrGFav
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