Aprecia Pharmaceuticals’ Post

𝗘𝗹𝗲𝗰𝘁𝗿𝗼𝗮𝗰𝘁𝗶𝘃𝗲 𝗣𝗼𝗹𝘆𝗺𝗲𝗿𝘀 𝗳𝗼𝗿 𝗢𝗻-𝗗𝗲𝗺𝗮𝗻𝗱 𝗗𝗿𝘂𝗴 𝗥𝗲𝗹𝗲𝗮𝘀𝗲 by Manal Alkahtani, Moe Elbadawi, Christopher Chapman, Rylie Green, Simon Gaisford, Mine Orlu, and Abdul Basit In this review, recent developments in Conductive Polymers (CP) as electroactive polymers for voltage-stimuli responsive drug delivery systems are evaluated. The review demonstrates the distinct drug release profiles achieved by electroactive formulations, and both the precision and ease of stimuli response. Read more in the article. #Pharmaceuticals #ConductivePolymers #Formulation

#TheoreticalTuesdays Current Overview of Oral Thin Films The pharmaceutical industry is attempting to discover thin films as a new drug delivery system. Thin films have been described as an alternative approach to conventional dosage forms. They are a versatile platform that provides fast, local, or systemic effects. Additionally, these systems can be easily applied by themselves, especially for dysphagia patients, geriatric, pediatric, or bedridden patients, as well as patients who cannot easily access water. These drug delivery systems can be administered in various ways such as orally, buccally, sublingually, ocularly, and transdermally. This review examines oral thin films in all aspects from today’s point of view and gives an idea about the growing market share in the world due to the increase in research fields and technological developments. At the same time, it provides an overview of the critical parameters associated with formulation design that affect of thin films, including the design of thin films, anatomical and physiological limitations, the selection of appropriate manufacturing processes, characterization techniques, and the physicochemical properties of polymers and drugs. It also provides insight into the latest thin-film products developed by various pharmaceutical companies. Pharmadeep Turnkey, was instrumental in Designing an Oral Thin Film manufacturing facility for India’s one of the leading OTF manufacturer. For more information, connect with us at jv@pharmadeep.com or Whatsapp us at +91-9372767093 today!! Content credit: National Library of Medicine  To read more: https://lnkd.in/dfmMpzBx. #pharma #planning #pharmaceuticalindustry #pharmaceutical #projectmanagement #consultancy #topconsultant #india #africa #russia #projectexecution #fromscratch #greenfieldproject #mepengineering #team #affordableprices #makeinindia #engineering #engineeringservices #layoutdesign #cleanroom #security #trending #2023planning 

𝗛𝗠𝗘 𝗮𝘀 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝗱 𝗔𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝗳𝗼𝗿 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗼𝗳 𝗦𝗼𝗹𝗶𝗱 𝗦𝗲𝗹𝗳 𝗘𝗺𝘂𝗹𝘀𝗶𝗳𝘆𝗶𝗻𝗴 𝗗𝗿𝘂𝗴 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝗦𝘆𝘀𝘁𝗲𝗺 The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology’s promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot melt extrusion (HME) technology is increasingly being used for novel applications. Because it has low-cost scale-up capabilities and process automation, which reduce labour costs and capital expenditure. HME has become a crucial technique for pharmaceutical manufacturing and research applications involving drug delivery. In the development of new drug delivery systems, the novel use of the HME method offers a promising alternate strategy. Through a discussion of pertinent case studies, the current review examines the value of HME in the creation of innovative drug delivery systems Learn more: https://lnkd.in/eiydE_XK #hotmeltextrusion #excipients #drugdelivery

𝐈𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐭 𝐟𝐨𝐫 𝐚𝐥𝐥: 𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐭𝐡𝐞 𝐁𝐢𝐨𝐩𝐡𝐚𝐫𝐦𝐚𝐜𝐞𝐮𝐭𝐢𝐜𝐬 𝐂𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐒𝐲𝐬𝐭𝐞𝐦 (𝐁𝐂𝐒) Dear LinkedIn Friends, The Biopharmaceutics Classification System (BCS) is a pivotal framework in pharmaceutical development, guiding the categorization of drugs based on their 𝐬𝐨𝐥𝐮𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐩𝐞𝐫𝐦𝐞𝐚𝐛𝐢𝐥𝐢𝐭𝐲. This system, essential for drug formulation and regulatory processes, divides compounds into four distinct classes: 1. 𝐂𝐥𝐚𝐬𝐬 𝐈: High Solubility, High Permeability - These drugs are typically well absorbed and have an absorption rate that surpasses their excretion rate. 2. 𝐂𝐥𝐚𝐬𝐬 𝐈𝐈: High Permeability, Low Solubility - The bioavailability of these drugs is generally 𝐥𝐢𝐦𝐢𝐭𝐞𝐝 𝐛𝐲 𝐭𝐡𝐞𝐢𝐫 𝐫𝐚𝐭𝐞 𝐨𝐟 𝐬𝐨𝐥𝐯𝐚𝐭𝐢𝐨𝐧. 3. 𝐂𝐥𝐚𝐬𝐬 𝐈𝐈𝐈: Low Permeability, High Solubility - While these drugs dissolve quickly, their absorption is limited by permeation rates. 4. 𝐂𝐥𝐚𝐬𝐬 𝐈𝐕: Low Solubility, Low Permeability - These drugs often exhibit poor bioavailability and are not well absorbed through the intestinal mucosa. 𝐖𝐡𝐲 𝐢𝐬 𝐁𝐂𝐒 𝐈𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐭 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭? BCS plays a crucial role in early-phase drug discovery, helping to assess the risks of oral absorption. This information is vital for developing effective chemical and formulation strategies. Most of the #PROTACs fall into class IV compounds. Hence, PROTACs pose significant challenges due to their low solubility and permeability, leading to suboptimal patient outcomes and variable pharmacokinetics. To enhance oral absorption of these compounds, formulation strategies often focus on solubility/dissolution enhancement. 𝐈𝐧𝐧𝐨𝐯𝐚𝐭𝐢𝐯𝐞 𝐀𝐩𝐩𝐫𝐨𝐚𝐜𝐡𝐞𝐬 𝐢𝐧 𝐁𝐂𝐒 𝐂𝐥𝐚𝐬𝐬 𝐈𝐕 For BCS Class IV compounds, the aim is to achieve supersaturation through various methods like forming micelles, nanoparticles, or amorphous particles. These techniques may increase drug transport across the intestinal membrane through several mechanisms, offering new research avenues and questions in pharmaceutical development. 𝐊𝐞𝐲 𝐓𝐚𝐤𝐞𝐚𝐰𝐚𝐲 Understanding the BCS classification is crucial for drug hunter and pharmaceutical professionals as it guides the effective formulation and development of new drugs, ensuring higher success rates. With regards, Purushottam Dewang MetaG1 Research Consortium #Biopharmaceutics, #DrugDevelopment, #PharmaceuticalScience, #BCSClassification, #DrugSolubility, #DrugPermeability, #innovation #Pharmacokinetics, #FormulationStrategies, #PharmaInnovation, #ClinicalPharmacology, #MedicinalChemistry, #DrugDiscovery, #PharmaIndustry, #Pharmaceuticals

🧪Drug Product Solution for Drugs with Low Solubility🧪 👄Oral drug delivery, favored for patient compliance and cost-effectiveness, poses challenges for drugs with low solubility. Amorphous solid dispersions (ASDs) offer a solution, enhancing solubility and bioavailability. ASDs prevent recrystallization by incorporating stabilizing polymers, like hydroxypropyl methylcellulose acetate succinate (HPMCAS), and maintaining high glass transition temperatures (Tg). ⚗️New advances, such as high loaded dosage forms (HLDF), optimize ASDs by dividing stabilization duties between polymers, reducing dosage form burden by 40%. Innovations also streamline development timelines with in vitro techniques like high-throughput UV testing, minimizing manufacturing and testing needs. Biorelevant dissolution testing and absorption modeling enhance in vivo performance prediction. 🔬Overall, ASDs effectively improve poorly soluble drug delivery, with ongoing advancements promising faster development and enhanced product attributes. #pharmaceuticals #cdmo #researchanddevelopment #pharmaceuticalmanufacturing #apidevelopment #pharmaindustry #drugdiscovery #smallmolecule #cmcs #chemistrythatmatters #PharmaCDMO #drugdevelopment #contractmanufacturing #CMOservices #pharmasupplychain

𝗧𝗵𝗲 𝘀𝗰𝗶𝗲𝗻𝗰𝗲 𝗼𝗳 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝘀𝘂𝘀𝗽𝗲𝗻𝘀𝗶𝗼𝗻𝘀 𝗲𝘅𝗽𝗹𝗮𝗶𝗻𝗲𝗱! – 𝗘𝘅𝗽𝗹𝗮𝗶𝗻𝗲𝗿 𝘃𝗶𝗱𝗲𝗼 𝗯𝘆 𝗣𝗵𝗮𝗿𝗺𝗮 𝗗𝗿𝗮𝗺𝗮 In this video 𝗣𝗵𝗮𝗿𝗺𝗮 𝗗𝗿𝗮𝗺𝗮 𝗮𝗸𝗮 Simon Gaisford explains how suspensions are formulated and what the medicine is trying to achieve in terms of their properties. #pharmaceutical #suspensions https://lnkd.in/ebxsQZxR

𝗧𝗵𝗲 𝘀𝗰𝗶𝗲𝗻𝗰𝗲 𝗼𝗳 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝘀𝘂𝘀𝗽𝗲𝗻𝘀𝗶𝗼𝗻𝘀 𝗲𝘅𝗽𝗹𝗮𝗶𝗻𝗲𝗱! – 𝗘𝘅𝗽𝗹𝗮𝗶𝗻𝗲𝗿 𝘃𝗶𝗱𝗲𝗼 𝗯𝘆 𝗣𝗵𝗮𝗿𝗺𝗮 𝗗𝗿𝗮𝗺𝗮 In this video Pharma Drama aka Prof. Simon Gaisford explains how suspensions are formulated and what the medicine is trying to achieve in terms of their properties. See the video and read the full transcript here: https://lnkd.in/dbcK8QYS

More than 80% of NCEs are poorly soluble compounds, making solubilization a critical factor in the formulation stage of the drug development process. Overcoming this challenge using lipid nanoparticles is essential to move your drug product through the development pipeline. Conventional formulation technologies can pose obstacles when it comes to compatibility with excipients and processing conditions used in manufacturing. Lipids used in drug development products have improved suitability and greater drug delivery efficiency. However, each API presents various complications for nanosizing, such as unwanted toxicity and side effects, making it crucial to find the appropriate formulation technologies and strategies to help prevent unwanted side effects in clinical studies and in post launch marketed drugs. Ascendia shares how a #CDMO partner with proven success in creating formulations to overcome poor solubility can take your product to market on schedule and within budget.

New drug development is a challenging task, especially when it comes to oral medication delivery. Over 40% of new chemical entities are practically insoluble in water, which hinders their desired bioavailability. But here's some good news - complexation approaches offer a potential solution. Various complex types, such as metal, organic molecules, inclusion complexes, and pharmacosomes, can improve aqueous solubility, dissolution, and drug permeability. They can also enhance drug stability, reduce toxicity, and improve bioavailability and biodistribution. Scientists can use the information provided in this review to optimize their drug delivery systems, potentially improving patient outcomes. The review also covers various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex. #drugdelivery #complexation #bioavailability #formulationscience #pharmacology #pharmaceuticals #pharmaceuticalindustry

The #Gravimetricfiller, part of 3P’s #pharmaequipment Discover Range, which benefits from the world’s fastest gravimetric powder micro-dosing technology. https://lnkd.in/dRe_6z2N #pharmaceutical #pharmaceuticals #healthcare #pharmacology #pharma #medicine #health #pharmacystudent #science #niper #pharmd #biotech #pharmacists #pharmacytechnician #doctors #pharmacylife #farmacia #biotechnology #pharmacognosy #research #inos #inostechnologies