Nanoform reposted this
Interested in Drug Discovery? These are 3 companies you should look at. Click through to learn more. 1) Drug Hunter "Our mission is to empower the innovators seeking tomorrow’s medicines." 2) Nanoform " Our mission is to support pharma companies as they develop life-changing medicines, by overcoming drug development & delivery challenges." 3) Persist AI "Life-saving drugs, delivered better" #drugdiscovery #drugdelivery #drugdevelopment I am also sharing Presentation of Wenzhan Y.. Full peer reviewed publication hereafter: For me, there is still nothing better even though it was first published in 2021 as it includes commercially available solutions as well. Yang, Wenzhan, et al. "Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development." Drug discovery today 26.3 (2021): 713-723. You should also check out this non-profit group PBSS International "The mission of PBSS is to promote the exchange of scientific ideas while providing educational and growth opportunities in the fields of pharmaceutical / life science related disciplines." https://lnkd.in/gBiFEwQh Shichang Miao, PhD, President, PBSS International Peter Staehr, M.D., MD, Chair, PBSS – San Francisco Bay Robyn Rourick, Chair, PBSS – San Diego Dinesh Chandra Prakash, PhD, Chair, Boston-PBSS Harvey Wong, PhD, Chair, Vancouver-PBSS Young Shin, PhD, Chair, Korea-PBSS
Tsung Tan
1mo
Yang, Wenzhan, et al. "Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development." Drug discovery today 26.3 (2021): 713-723. https://www.sciencedirect.com/science/article/abs/pii/S1359644620305262
Tsung Tan
1mo
Thinking more about the future? Please see my original share. https://www.linkedin.com/posts/tantzetsung_the-future-of-drug-delivery-activity-7087608302016073730-Dpc3
Tsung Tan
1mo
Here is another publication from Wenzhan Yang et al. #PROTACs https://www.linkedin.com/posts/wenzhan-y-19415a1b_early-evaluation-of-opportunities-in-oral-activity-7150174516445417472-LJpB
Thanks for mentioning us Tsung! Much appreciated. We are keen to help the industry tackle some of the most challenging issues faced around bioavailability and drug loads in formulations especially as drug complexity increases. In fact, together with Drug Hunter we analysed all molecules launched in the market since 1970 to today and each decade synthetically derived molecules increased in LogP by 1. https://drughunter.com/articles/not-your-grandparents-drugs-how-approved-drugs-have-evolved-since-the-70s/ We need new technologies to enable the next generation of drug molecules for patient-centric medicine 💊 development. Feel free to check out a flash talk we did (Tamás Solymosi) with Drug Hunter and Dennis X. Hu around the formulation options available to med chemists today. https://youtu.be/xOY3JNoZN4w?si=o4poOPyd867sCMeO
Programmable & Targeted Drug Delivery, iprecio@Primetech.co.jp Worldwide.
1moHere are 3 papers and a book which cited Yang, Wenzhan, et al Matthew O'Brien Laramy, Ph.D. N., et al. "Challenges and opportunities in the development of complex generic long-acting injectable drug products." Journal of controlled release 336 (2021): 144-158. https://www.sciencedirect.com/science/article/abs/pii/S0168365921003047 Amit Dabke, et al. "Revisiting the in-vitro and in-vivo considerations for in-silico modelling of complex injectable drug products." Journal of Controlled Release 360 (2023): 185-211. https://www.sciencedirect.com/science/article/abs/pii/S0168365923004029 Divya Sharma, Ph.D., et al. "Experimental design, development and evaluation of extended release subcutaneous thermo-responsive in situ gels for small molecules in drug discovery." Pharmaceutical Development and Technology 26.10 (2021): 1079-1089. https://www.tandfonline.com/doi/abs/10.1080/10837450.2021.1985519 Sarfaraz K. Niazi The Future of Pharmaceuticals: A Nonlinear Analysis. CRC Press, 2022. https://www.taylorfrancis.com/books/mono/10.1201/9781003146933/future-pharmaceuticals-sarfaraz-niazi