Pere Clave’s Post

🎉Thrilled to announce the publication of my first PhD paper titled "A non-invasive tool to collect small intestine content in post-weaning pigs: validation study" in Scientific Reports! 📚🐷 🔍 In this article we present Capsule for Sampling (CapSa), an ingestible capsule that allows us to collect small intestine content from postweaning pigs as it journeys through the natural digestive pathway. In the future, this could allow us to gather crucial insights into the gut microbiota of post-weaning pigs without invasive methods! 🤔 🔬 Our study found that CapSa effectively samples the intestinal microbiota from the upper section of the small intestine, opening new avenues for research in microbiota research in pigs 🐖💫 🐽 This article was the result of a fruitful collaboration with the talented team at Agroscope (Posieux, Switzerland) (Catherine Ollagnier, Giuseppe Bee and the piggery team lead by Guy Maïkoff) and the University of Bologna (Alma Mater Studiorum – Università di Bologna) (Paolo Trevisi and Federico Correa)🧬💡 My research is part of the MonoGutHealth MSCA-ITN project. 📰 Check out the full article here: https://lnkd.in/ezfQb4Av #PhD #Research #GutMicrobiota #AnimalHealth #Innovation #MonoGutHealth #MSCA #H2020 #scicomm

A great collaboration among Vitalab Srl and #shanghaiuniversityofTCM to create the revolution in #skinlongevity, harvesting the full power of the most potent TCM of them all: cordyceps. Discover more on the scientific publication about #CordysReVitagen

7. CONCLUSIONS Saliva is a major contributor to oral and overall health and well-being. Thus, understanding the mechanisms that lead to loss of secretion and those involved in functional organ regeneration remains a major focus of current and future research. There has been great progress in understanding the biology of SG development and hypofunction thanks to the advent of OMICS technologies combined with more advanced animal models that mimic different aspects of disease in humans. https://lnkd.in/gTst3MCJ

We have never realised that oral health is a gateway & mirror of overall health. Did you know 51% of Indian adults have gum disease? While we may ignore our gum & dental issues till the time pain become unbearable more so because of high cost of routine dental care, these are indications that we are already suffering from systemic health conditions which are yet to reflect in POC diagnostic tests Yes you heard it right! -Gum Health & Heart Health are connected -Progression of Periodontal Disease is connected with onset of type 2 diabetes  -Gum Health is connected with preterm births & dementia Routine oral care  may do away with the current high cost of root canals & other operative procedures but it creates a huge future healthcare & disease management cost which we could not foresee.So how does oral health translate into overall body health? Yes- it is the oral microbiome- our mouth harbours 100 billion microbes which perform various biological processes. These microbes -Predigest the food & makes it available for absorption in small intestine & colon -Secrete metabolites that acts as biochemical signals, interacting with various body organs including gut microbiome & telling what is coming their way A lot of these are commensals but improper nutrition choices, use of fluoride rich toothpaste & mouthwash could make these commensals express virulence genes & convert pathogenic. This turn on of virulence genes codes for protein that lead to secretion of harmful metabolites that stimulates immune system response & trigger pro-inflammatory responses. On a lot of occasions, this prevalent & ongoing inflammation results in leaky mouth &  allows metabolites & even microbes to enter the bloodstream & translocate to different body organs, resulting in a wave of systemic inflammation- causing type 2 diabetes, heart disease, dementia & more Unfortunately, these early signals at the molecular level asymptomatic are not decoded by our standard clinical tests.  Symptoms such as gum bleeding, bad breath, white coating on tongue & more show up years after these molecular signals manifest What if you could learn about these signals when they arise, around 2 decades before symptoms show up? What if your dentists have this molecular level data beforehand? What if you can neutralise these signals by personalising nutrition as medicine? What if you could save a lot of future healthcare costs & economic burden. https://lnkd.in/gnmcrdi6 We at Genefitletics have built Asia’s first & only system biology platform that analyses downstream functions of oral microbiome to measure hard to detect/asymptomatic molecular signals & compute precision nutrition to rebalance your oral biology. More details here: www.genefiteltics.com #oralhealth #gumdisease #type2diabetes #cardiovasculardisease #dementia Sakshi Bali Shashi Shekhar M. Dr Kamal Karnatak Tarun Kumar

After many years of research and data collection and integration from multiple scientific disciplines, we believe we arrived at an understanding of the redox processes that take place in biological systems that challenges to large extent the current understanding of the phenomenon and at the same time offers a new perspective of it, with far reaching implications. As it is clear that the current frame of reference in healthcare does not offer the right solutions, we aim to present the information in a new, different frame of reference that will enable the development of the right therapeutic approaches. The awareness of the central role oxidative and reductive stress play in the pathophysiology of many acute and chronic and degenerative diseases is quite high in the naturopathic and alternative medicine sectors, but it is still very limited in mainstream medicine and dentistry.  We believe this awareness must reach mainstream levels and we aim to contribute to that goal. While targeted therapies for redox homeostasis are limited, currently, to combinations of natural antioxidant extracts and vitamins, there is very limited testing of the level of oxidative stress in the subjects, leading to high risk of converting oxidative stress to reductive stress, among others. There is high value in knowing the levels of pro-oxidant and anti-oxidant status in subjects receiving antioxidant therapies and not only. It empowers the healthcare professionals to adjust and maximize the outputs of their therapeutic protocols. We will start sharing our accumulated knowledge and insights in a series of posts on the company page and will correlate the information with the importance of testing for oxidative stress in general and with our unique FRAS5 testing system in particular. #redoxhomeostasis #oxidativestress #reductivestress #FRAS5 #dROMstest #PATtest #OxidativeStressIndex #InnovaticsLaboratories

A human-to-human microbiome transfer without fecal matter could potentially be achieved through the transplantation of cultured microbiota. This process would involve: 1. Identifying and isolating beneficial microbial strains from healthy donors. 2. Culturing these strains in a lab to multiply their numbers. 3. Encapsulating these strains into a stable, ingestible form. Additionally, methods like using a donor's oral microbiota or skin microbiota are being researched. These methods would involve transferring microbes from these areas, which have their own distinct communities, to the recipient, possibly through swabs or topical preparations. However, whether these methods would be effective for gastrointestinal issues is still under investigation. The key would be ensuring the transplanted microbes can survive and colonize the gut environment where they are needed. Visualize a bright, modern lab with a central workstation illuminated by overhead lights. Scientists are carefully transferring cultured bacteria into capsules. Above them, a digital display shows a colorful array of bacterial cultures, each labeled with a potential health benefit. On the right, a graphic illustrates the encapsulation process, while on the left, there’s a happy, healthy family symbolizing the end recipients. The image conveys cleanliness, precision, and the high-tech nature of this innovative microbiome transfer process. #MicrobiomeCulturing #GutHealthRevolution #NextGenProbiotics #HumanMicrobiomeTransfer #NonFecalMicrobiotaTx #MicrobialTherapy #CulturedMicrobiota #OralMicrobiomeTransfer #SkinMicrobiotaTherapy #InnovativeMicrobiomeSolutions

Interesting study exploring the use of non-invasive device for the collection and analysis of intestinal microbiota in post-weaning pigs https://lnkd.in/efNSf_RB

Consuming a multi-species probiotic formulation containing Lactobacillus rhamnosus and Bifidobacterium lactis has been shown in a clinical trial to have positive effects on mental well-being and cognitive functions in healthy older adults. This study highlights the potential of probiotics in improving cognitive and emotional states by targeting the gut-brain axis, suggesting a promising avenue for natural interventions in maintaining brain health and emotional well-being. #Probiotics #GutBrainAxis #CognitiveHealth #EmotionalWellBeing #Biohacking Read more here: https://lnkd.in/d6EgxbRB BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

We recently organized the #GUTday conference to spotlight the importance of #guthealth as a foundation of our overall well-being. GUTday brought together a diverse group of passionate experts in family medicine, nutrition, psychology, gastroenterology, dermatology, and food sciences. The event featured a series of insightful presentations centered around the fascinating world of the gut microbiome. Attendees were thrilled to delve into various captivating topics, including the profound impact of gut health on #mentalwellbeing and practical, life-changing approaches to improving gut health through diet and lifestyle modifications. 💡 Did you know that taking a 14-day course of antibiotics can massively damage the diversity of the microbiome, and it may take more than a year to restore it? The diversity of the microbiome plays a pivotal role in preventing and managing a wide range of health conditions. GUTday provided an incredible platform for networking and collaboration, fostering a vibrant sense of community among participants. 🚀 The first GUTday was a stepping stone, sparking ideas for the next conference already. Thank you RTU Science and Innovation Centre and Alina Dolmate for your support in making this happen.🙏 #fermentedfoods #foodasmedicine #biotech #futurefoods #sustainability #plantbasedfoods

How does daily activity affect the gut microbiome? We sat down with Dr. Lawrence Kosinski, gastroenterologist, founder of SonarMD and Jona’s Chief Medical Officer, to answer this exactly, and learn more about how he uses microbiome science in his own practice. We are excited to continue sharing with you snippets of the interview over the next few weeks. Stay tuned! Continue learning via the Jona website about how you can get your hands on a test kit, https://lnkd.in/gdx8Tsd8. #guthealth #leakygut #guthealing #guthealthmatters #wellness #ibs #ibsdiet #probiotics #ibsawareness #gutmicrobiome #healthygut #digestivehealth #microbiome #digestion #holistichealth #foodismedicine #probiotic #probioticsupplements #gutfriendly #microbiomescience #microbiology