Seed Health’s Post

"Gastrointestinal candidiasis will progress to invasive candidiasis (leaky gut syndrome)! As the number of infectious invaders within the gut increases, inflammation within the gut wall and tissues occurs; they become irritated, swollen, impaired, and even injured. As a result, the gut wall becomes weakened and increasingly fragile, making it easier to disturb with each additional insult. Eventually, as the insults accumulate, the gut wall can be breached, which allows inappropriate substances to enter the tissues, while fluid and other substances can leak out. Damage to the gut wall does not happen spontaneously. Instead, disease-causing yeast readily participate. Under optimal conditions, when they are well-fed, disease-causing yeast typically remain in their less-aggressive ovoid form. However, when their environment is compromised, some disease-causing yeast can transform into a more aggressive, invasive form called a mycelium, with a main body and numerous, extending branches called hyphae or pseudo-hyphae, like a tree-trunk and its branches. Even though the ovoid form can enter the gut wall and tissues when its survival is at stake, research reveals the mycelial form is much more effective at invading the gut wall; it produces enzymes that digest protein and other components within the gut wall, allowing it to more easily invade into the gut wall to obtain nutrition. The mycelial form of disease-causing yeast can digest its surrounding tissue, creating tiny “holes” in the gut wall that allow undigested food particles and other inappropriate substances to leak through, a condition called leaky gut syndrome. In return, the wall and mucous membranes can become irritated, impaired, injured, and even damaged, from microscopic to grossly visible, localized, patchy, or widespread. Depending on the location and severity, colonization and invasion can cause or exacerbate one or more gastrointestinal problems, including oral thrush, esophagitis, gastritis, duodenitis, ulcers, irritable bowel syndrome, inflammatory bowel disease, colitis, spastic colon, and proctitis (“Unraveling Candidiasis” - chapter 4) In most candidiasis sufferers, their gastrointestinal candidiasis will progress to invasive candidiasis sooner or later. Therefore, a comprehensive approach to diagnosis and treatment is usually required." - by Dr. Marc Bielski for Little Spirit Books #candida #microbiome #holistichealth #integrativemedicine

*The 19th ECCO'24: A Spotlight on the De Simone Formulation and Mendes SA* The 19th Congress of the European Crohn’s and Colitis Organization (ECCO) in Stockholm on February 21-24, 2024, will feature a significant recognition of the De Simone Formulation (DSF). Today the ECCO Guidelines exclusively endorse the DSF, supported by scientific evidence, as posted in the Journal of Crohn’s and Colitis. All physicians and Key Opinion Leaders are welcome to visit the international booth for the DSF. An excellent opportunity to learn more about DSF and its impact on probiotics for inflammatory bowel diseases. Moreover, the Satellite Lunch Symposium on Friday, February 23, with Prof. Claudio De Simone and Prof. Paolo Gionchetti, offers an opportunity for all partners to show their support to the inventor of DSF, the stronghold of all our products. Your participation will contribute to the ongoing dialogue about the future of probiotics and the DSF in IBD. *Professor Claudio De Simone: A Pioneer in Probiotic Research* Professor Claudio De Simone, MD, PhD, is an internationally recognized leader in the field of probiotics and the human gut microflora. His formulation known as the “De Simone Formulation” and sold in Europe under the brand Vivomixx® has been the subject of over 280 publications. The DSF has been integrated into international treatment guidelines and Prof De Simone's pioneering work in the field of intestinal microflora led to significant advancements in the understanding and management of conditions such as pouchitis, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and Hepatic Encephalopathy. Learn more : https://lnkd.in/dfGc7j4P #dsf #boweldisease #inflammatoryboweldiseases #inflammatoryboweldisease #ecco24 #scientificevidence #stockholm #crohn #pouchitis #irritablebowel #ibd #ibs #desimone #boweldisease #bowelsyndrome #irritablebowelsyndrome #gut #guidelines

Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction. Heart failure with preserved ejection fraction (HFpEF) is a common but poorly understood form of heart failure, characterized by impaired diastolic function. It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult. METHODS: Metabolomic analyses in a mouse model of HFpEF showed that levels of indole-3-propionic acid (IPA), a metabolite produced by gut bacteria from tryptophan, were reduced in the plasma and heart tissue of HFpEF mice as compared with controls. We then examined the role of IPA in mouse models of HFpEF as well as 2 human HFpEF cohorts. RESULTS: The protective role and therapeutic effects of IPA were confirmed in mouse models of HFpEF using IPA dietary supplementation. IPA attenuated diastolic dysfunction, metabolic remodeling, oxidative stress, inflammation, gut microbiota dysbiosis, and intestinal epithelial barrier damage. In the heart, IPA suppressed the expression of NNMT (nicotinamide N-methyl transferase), restored nicotinamide, NAD(+)/NADH, and SIRT3 (sirtuin 3) levels. IPA mediates the protective effects on diastolic dysfunction, at least in part, by promoting the expression of SIRT3. SIRT3 regulation was mediated by IPA binding to the aryl hydrocarbon receptor, as Sirt3 knockdown diminished the effects of IPA on diastolic dysfunction in vivo. The role of the nicotinamide adenine dinucleotide circuit in HFpEF was further confirmed by nicotinamide supplementation, Nnmt knockdown, and Nnmt overexpression in vivo. IPA levels were significantly reduced in patients with HFpEF in 2 independent human cohorts, consistent with a protective function in humans, as well as mice. CONCLUSIONS: Our findings reveal that IPA protects against diastolic dysfunction in HFpEF by enhancing the nicotinamide adenine dinucleotide salvage pathway, suggesting the possibility of therapeutic management by either altering the gut microbiome composition or supplementing the diet with IPA. Source: Circ Res https://lnkd.in/ejp6FPFe

Iam happy to share my article about Pancreas. #snsinstitutions #snsdesignthinking #snsdesignthinkers The pancreas is an important organ located in the abdomen, behind the stomach. It plays a vital role in digestion and the control of blood sugar levels. Here are some key points about the pancreas: 1. Anatomy: The pancreas is approximately 6 inches long and has a tadpole-like shape. It is divided into three main parts: the head, body, and tail. 2. Exocrine function: The exocrine part of the pancreas produces and releases digestive enzymes into the small intestine through a duct system. These enzymes help break down proteins, fats, and carbohydrates in the food we eat. 3. Endocrine function: The endocrine part of the pancreas consists of clusters of specialized cells called islets of Langerhans. These cells release hormones that help regulate blood sugar levels, including insulin and glucagon. 4. Insulin: Insulin is a hormone produced by beta cells in the pancreas and is crucial for lowering blood sugar levels by facilitating the uptake of glucose into cells. 5. Glucagon: Glucagon, produced by alpha cells in the pancreas, has the opposite effect of insulin. It raises blood sugar levels by stimulating the liver to release stored glucose. 6. Pancreatic disorders: The pancreas can be affected by various conditions, including pancreatitis (inflammation of the pancreas), pancreatic cancer, cysts, and pancreatic insufficiency. 7. Pancreatic insufficiency: This condition occurs when the pancreas is unable to produce enough digestive enzymes. It can lead to malabsorption issues and nutrient deficiencies. 8. Diabetes: Type 1 diabetes occurs when the pancreas doesn't produce enough insulin due to autoimmune destruction of the beta cells. In type 2 diabetes, the body becomes resistant to the effects of insulin, and the pancreas may struggle to produce enough insulin to compensate. 9. Pancreatic tumors: Pancreatic tumors can be benign (non-cancerous) or malignant (cancerous). Symptoms may include abdominal pain, weight loss, jaundice, and digestive problems. 10. Diagnostic tests: Medical professionals can evaluate pancreatic function through blood tests, imaging studies (such as CT scan or MRI), endoscopic procedures, and biopsies. It's important to seek medical advice from a healthcare professional if you have any concerns or symptoms related to your pancreas.

Gut microbiota facilitate chronic spontaneous urticaria. Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics and assess the effects of human CSU fecal microbial transplantation, Klebsiella pneumoniae, Roseburia hominis, and metabolites in vivo. CSU gut microbiota displays low diversity and short-chain fatty acids production, but high gut Klebsiella pneumoniae levels, negatively correlates with blood short-chain fatty acids levels and links to high disease activity. Blood lipopolysaccharide levels are elevated, link to rapid disease relapse, and high gut levels of conditional pathogenic bacteria. CSU microbiome transfer and Klebsiella pneumoniae transplantation facilitate IgE-mediated mast cell(MC)-driven skin inflammatory responses and increase intestinal permeability and blood lipopolysaccharide accumulation in recipient mice. Transplantation of Roseburia hominis and caproate administration protect recipient mice from MC-driven skin inflammation. Here, we show gut microbiome alterations, in CSU, may reduce short-chain fatty acids and increase lipopolysaccharide levels, respectively, and facilitate MC-driven skin inflammation. Source: Nat Commun https://lnkd.in/eJJ2AUCC

3 COMMON CLOVE ESSENTIAL OIL BENEFITS With all of that antioxidant healing power of eugenol in clove essential oil (CEO), you probably already have a feel for the potential that it carries. With great power comes great responsibility, though, and clove essential oil carries as much potential for damage as it does for healing. A recent study, published in the Journal of Immunotoxicology, demonstrates this balance between effectiveness and caution. After investigating the effects of eugenol – CEO’s most prominent property – on the liver, they discovered two sides of one coin. Eugenol in low doses protected the liver, not only against at least one cause of liver disease but also against inflammation and cell death. On the other hand, “a larger dose amplifies the liver injury via oxidant and inflammatory effects.” (3) This is both good news and a warning: CEO is a powerful substance. Powerful substances should be handled carefully, under the guidance of knowledge, wisdom, and common sense. With this caution in mind, we can explore the clove essential oil benefits when used safely and appropriately – and there are many benefits! We’ve already seen clove essential oil uses related to anti-inflammatory capability, and with inflammatory illness so heavily plaguing our society, you can imagine the implications that has. There are other effects of eugenol that make CEO beneficial for disease prevention and oral health. Let’s explore just a few of these properties in light of current research regarding clove essential oil uses. 1. ANTIBACTERIAL Clove essential oil is widely understood to be generally antibacterial, but the University of Buenos Aires took the time to pinpoint bacteria that clove was especially able to target. They found that E. coli was particularly susceptible to CEO, followed by Staph aureus and Pseudomonas aeruginosa. With all of these connected to significant illness, skin infections, and pneumonia, CEO is a valuable tool for disease prevention. (4) 2. ANTIFUNGAL Candida is a devastating, pervasive problem in our culture, and one that remains a personal soapbox of mine. Our diets high in sugar and acidification kill beneficial gut microbes and colonize Candida. In mainstream medicine, nystatin is used to manage yeast infections, though it never addresses the root causes and can bring side effects of its own. Published in the journal Oral Microbiology & Immunology, researchers weighed the effects of clove essential oil against nystatin in vitro, finding it just as effective, but as a natural substance rather than synthetic chemical concoction. (5) 3. ANALGESIC AND ANTISEPTIC Clove essential oil is a longtime dental remedy, dating back to 1640 in French documentation “Practice of Physic,” and beyond in Chinese tradition. To this day, clove remains a go-to for dental needs.

Title: Understanding the Portal Circulation Introduction The human body is a complex and intricate system with numerous vital functions that ensure our survival. One of these remarkable functions is portal circulation, a lesser-known but crucial aspect of our circulatory system. In this article, we will delve into the fascinating world of portal circulation, exploring its anatomy, functions, and clinical significance. Anatomy of Portal Circulation Portal circulation is a unique system that involves the transport of blood from one group of organs to another before returning to the heart. Unlike the typical circulation in which blood flows directly from the heart to organs and tissues, portal circulation involves an intermediate stop in the liver. The primary components of portal circulation are the portal vein, hepatic portal system, and the liver. The portal vein, a large blood vessel, collects blood from various organs such as the stomach, intestines, spleen, and pancreas. This nutrient-rich, oxygen-poor blood is then transported to the liver through the hepatic portal system. Within the liver, blood undergoes a series of vital processes, including filtration, detoxification, and nutrient processing. After passing through the liver, the now purified and nutrient-rich blood is released into the general circulation, eventually reaching the heart and being redistributed to the rest of the body. Functions of Portal Circulation 1. Nutrient Processing: One of the primary functions of portal circulation is to ensure that nutrients absorbed from the digestive system, such as glucose, amino acids, and vitamins, are processed and distributed effectively to the body's cells. 2. Detoxification: The liver acts as a detoxification center, removing harmful substances and toxins from the blood before it reaches the systemic circulation. This plays a crucial role in maintaining overall health. 3. Blood Volume Regulation: Portal circulation helps regulate blood volume in the body. By altering the amount of blood flowing through the liver, it can modulate the distribution of blood throughout the body. Clinical Significance 1. Portal Hypertension: When there's an increase in pressure within the portal vein, it can lead to portal hypertension. This condition can result from liver diseases, blood clots, or other factors, and it may lead to serious complications like variceal bleeding and ascites. 2. Cirrhosis: Cirrhosis is a condition in which healthy liver tissue is replaced with scar tissue, often as a result of chronic liver disease or excessive alcohol consumption. This can disrupt portal circulation and lead to further complications. 3. Liver Transplantation: Understanding portal circulation is crucial in the context of liver transplantation, where surgeons need to carefully connect the donor's liver to the recipient's portal vein to ensure proper blood flow. #snsdesignthinkers #snsdesignthinking #snsinstitutions